目的　探讨帕罗西汀治疗功能性消化不良 (FD)的临床疗效。方法　将门诊 84人患FD的患者随机分成治疗组和对照组 ,均予以西沙必利治疗。治疗组加用帕罗西汀口服治疗。结果　治疗 4周后统计结果 ,治疗组显效 43 % ,有效 40 % ,总有效率 83 % ,治疗组与对照组的疗效有显著性差异 ,P <0 0 1。结论　帕罗西汀与西沙必利联合使用可显著提高治疗功能性消化不良的疗效 ,值得推广 Objective To investigate the clinical efficacy of paroxetine in the treatment of functional dyspepsia (FD). Methods Eighty-four outpatients with FD were randomly divided into treatment group and control group, all treated with cisapride. The treatment group plus paroxetine oral treatment. Results After 4 weeks of treatment, the treatment group showed a significant effect of 43%, effective 40% and total effective rate of 83%. There was significant difference between the treatment group and the control group (P <0.01). Conclusions The combination of paroxetine with cisapride significantly improves the efficacy of treatment of functional dyspepsia and is worth promoting