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目的探讨参附注射液对脓毒症患者血清肌钙蛋白I(c Tn I)、N-末端脑钠肽前体(NT-pro BNP)水平及心脏指数的影响。方法选取2012年5月—2015年5月南京第一医院收治的脓毒症患者60例,采用随机数字表法分为对照组和观察组,每组30例。对照组患者采用常规西医对症治疗,观察组患者在常规西医治疗的基础上给予参附注射液。比较两组患者治疗前后血清c Tn I、NT-pro BNP水平及心脏指数。结果两组患者治疗前血清c Tn I、NT-pro BNP水平及心脏指数比较,差异无统计学意义(P>0.05);观察组患者治疗后血清c Tn I、NT-pro BNP水平低于对照组,心脏指数高于对照组(P<0.05)。两组患者治疗后血清c Tn I、NT-pro BNP水平低于治疗前,心脏指数高于治疗前(P<0.05)。结论参附注射液能够降低脓毒症患者血清c Tn I、NT-pro BNP水平,提高患者心脏指数。
Objective To investigate the effect of Shenfu injection on serum cTnI, NT-pro BNP and cardiac index in septic patients. Methods Sixty patients with sepsis admitted to Nanjing No.1 Hospital from May 2012 to May 2015 were randomly divided into control group and observation group with 30 cases in each group. Patients in the control group were treated with conventional western medicine symptomatic treatment. Patients in the observation group were given Shenfu Injection on the basis of conventional Western medical treatment. The levels of cTn I, NT-pro BNP and cardiac index were compared between the two groups before and after treatment. Results There was no significant difference in serum cTn I, NT-pro BNP and cardiac index between the two groups before treatment (P> 0.05). The levels of cTn I and NT-pro BNP in the observation group were lower than those in the control Group, heart index higher than the control group (P <0.05). The levels of cTn I and NT-pro BNP in both groups after treatment were lower than those before treatment, and the cardiac index was higher than before treatment (P <0.05). Conclusion Shenfu injection can reduce serum cTn I, NT-pro BNP levels and improve cardiac index in septic patients.