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目的探讨Fisher综合征的临床特点,以提高对本病的诊治水平。方法回顾性分析11例Fisher综合征的发病机制、临床表现、治疗及预后。结果神经系统症状:眩晕、视物成双、四肢轻无力、手足麻木,主要神经系统体征:眼外肌麻痹、腱反射减弱或消失、共济失调等。脑脊液蛋白升高9例(0.5～1.8g/L,平均0.85g/L),细胞数均正常,肌电图示神经性损害9例,CT和MRI检查均未发现异常,免疫球蛋白可有效缓解病情。结论 Fisher综合征呈相对良性病程,预后较好,免疫球蛋白治疗有效。
Objective To investigate the clinical features of Fisher syndrome in order to improve the diagnosis and treatment of this disease. Methods Retrospective analysis of 11 cases of Fisher’s syndrome pathogenesis, clinical manifestations, treatment and prognosis. Results Neurological symptoms: dizziness, depending on the material in pairs, limbs weakness, numbness of hands and feet, major neurological signs: extraocular muscle paralysis, tendon reflexes diminish or disappear, ataxia and so on. Cerebrospinal fluid protein increased in 9 cases (0.5 ~ 1.8g / L, an average of 0.85g / L), the cell number were normal, EMG showed nerve damage in 9 cases, CT and MRI were found no abnormalities, immunoglobulin can be effective Ease the disease. Conclusion Fisher’s syndrome has a relatively benign course, the prognosis is good, and immunoglobulin is effective.