四十多年来,抗肿瘤药物的研究虽然已经有了很大的进展,并日益受到重视。但是,探索研制新的、更为有效的和毒性更低的抗癌药物,仍是一较长时期的重大课题。本文就具有抗癌活性的有机硅化合物的研究作一简述。 1.具有特殊结构的有机硅抗癌药物由于硅原子的独特性质,例如空的3 d轨道的利用、较小的电负性和较大的原子半径等,它可以制备一些具有特殊结构的有机硅化合物。 (1)水杨酸硅酯类: 水杨酸硅酯类药物1,是法国合成的治 Over the past 40 years, the research on anti-tumor drugs has made great progress and is receiving more and more attention. However, exploring new, more effective and less toxic anticancer drugs remains a major issue for a longer period of time. This article briefly reviews the research on the anti-cancer activity of organosilicon compounds. 1. Silicone anti-cancer drugs with special structure Due to the unique properties of silicon atoms, such as the use of empty 3-d orbitals, smaller electronegativity and larger atomic radius, it can prepare some organic structures with special structure Silicon compounds. (1) Silicon Salicylate: Silicon Salicylate Drugs 1, is the French synthesis of governance