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目的 观察两组常用神经阻滞镇痛液在不同时间不同温度下的理化性质变化。方法 第一组镇痛液由盐酸利多卡因注射液、维生素 B6 、维生素 B1 2 注射液、曲安奈德注射液、0 .9%氯化钠注射液组成 ,第二组镇痛液由盐酸利多卡因注射液、硫酸庆大霉素注射液、曲安奈德注射液、0 .9%氯化钠注射液组成。两组镇痛液在室温下分别于即刻、1 5min、3 0 min、60 min、1 2 0 min、2 4h( 3 6.5℃水温 ) ,测定 p H值 ,并观察颜色、沉淀的变化情况。结果 第一组镇痛液 p H值不同时间的变化为 3 .48、3 .5 5、3 .5 7、3 .5 0、3 .3 4、3 .2 4。第二组镇痛液 p H值不同时间的变化为 5 .1 9、5 .2 0、5 .2 5、5 .2 1、5 .1 1、4.0 5。结论 两组镇痛液 p H值均呈酸性和微酸性 ,并随时间延长而 p H下降。两组镇痛液配制后 1 5 min开始微细颗粒下沉 ,使用前必须充分摇混 ,以保证治疗效果。镇痛液配制后不宜久放 ,最好不超过 1 2 0 min。
Objective To observe the change of physicochemical properties of analgesic solution of nerve block in two groups at different temperatures. Methods The first group of analgesics consisted of lidocaine hydrochloride injection, vitamin B6, vitamin B1 2 injection, triamcinolone acetonide injection and 0.9% sodium chloride injection. The second group of analgesics consisted of lidocaine hydrochloride Caine injection, gentamicin sulfate injection, triamcinolone acetonide injection, 0.9% sodium chloride injection. The two groups of analgesics at room temperature, respectively, immediately, 15min, 30min, 60min, 120min, 24h (3 6.5 ℃ water temperature), measured p H value, and observe the color, precipitation changes. Results The change of p H value of the first group of analgesics was 3.48, 3.55, 3.57, 3.500, 3.33, 3.24. The pH values of the second group of analgesic fluid changed at different times to 5 .1 9,5 .2 0,5 .2 5,5 .2 1,5 .1 1,4.0 5. Conclusion The p H values of analgesic solution in both groups were acidic and slightly acidic, and decreased with time. Two groups of analgesics after the preparation of micro-particles began to sink 15 min after use must be fully shaken before use to ensure the therapeutic effect. Analgesic preparation should not be long after the release, preferably not more than 120 min.