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目的:分析慢阻肺患者发生侵袭性肺曲霉菌病(IPA)的独立危险因素。方法:收集2011.11-2015.01于我院住院诊断为慢阻肺合并侵袭性肺曲霉菌病患者31例,随机抽取同时期慢阻肺未合并有曲霉菌感染患者38例,应用单因素logistic回归分析两组的相关变量。结果:应用大量激素、BODE指数偏高、长时间应用广谱抗生素、有创通气与慢阻肺患者发生侵袭性肺曲霉菌病正相关,其OR、P值分别为(5.12,0.01)、(4.34,0.02)、(4.67,0.01),(3.18,0.04)。结论:长期应用大量激素、BODE指数大于8、长期应用广谱抗生素、有创通气与慢阻肺患者发生侵袭性肺曲霉菌病正相关,为发生侵袭性肺曲霉菌病的独立危险因素,慢阻肺患者有以上高危因素的应警惕侵袭性曲霉菌病。
Objective: To analyze the independent risk factors of invasive pulmonary aspergillosis (IPA) in patients with COPD. Methods: Totally 31 patients diagnosed as chronic obstructive pulmonary disease complicated with pulmonary aspergillosis in our hospital from 2011.11 to 2015.01 were collected. Thirty-eight patients with COPD were randomly selected from the same COPD patients. Univariate logistic regression analysis Group related variables. Results: With a large amount of hormones, the BODE index was high and broad-spectrum antibiotics were used for a long time. Invasive ventilation was positively correlated with invasive pulmonary aspergillosis in COPD patients. The OR and P values were (5.12,0.01), ( 4.34, 0.02), (4.67, 0.01), (3.18, 0.04). CONCLUSIONS: Long-term use of large quantities of hormones with a BODE of greater than 8 is associated with long-term use of broad-spectrum antibiotics. Invasive ventilation is associated with invasive pulmonary aspergillosis in COPD patients and is an independent risk factor for invasive pulmonary aspergillosis. Patients with pneumoconiosis have the above risk factors should be vigilant invasive aspergillosis.