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采用大鼠烟雾吸入伤模型，动态观察了伤后血浆、支气管肺泡灌洗液（ＢＡＬＦ）和肺组织中超氧化物歧化酶（ＳＯＤ）活性、丙二醛（ＭＤＡ）和共轭二烯（ＣＤ）含量的变化，辅以动脉血气分析、肺水量测定、ＢＡＬＦ中白细胞分类计数和病理检查．结果发现，伤后动物出现急性呼吸衰竭和严重肺水肿，肺内大量炎细胞聚集浸润；血浆、ＢＡＬＦ及肺组织中ＳＯＤ活性明显降低，ＣＤ和ＭＤＡ含量显著增加，ＭＤＡ／ＳＯＤ比值亦明显增高，且与ＢＡＬＦ中中性粒细胞数增加显著相关，提示氧化与抗氧化平衡失调可能在急性烟雾吸入性肺损伤的发生发展中起重要作用
The smoke inhalation injury model in rats was used to observe the activity of superoxide dismutase (SOD), malondialdehyde (MDA) and conjugated diene (CD) in the plasma, bronchoalveolar lavage fluid (BALF) Changes in content, supplemented by arterial blood gas analysis, lung water volume, white blood cell count and pathological examination in BALF. The results showed that acute respiratory failure and severe pulmonary edema occurred in the injured animals, and a large number of inflammatory cells accumulated and infiltrated in the lungs. The SOD activity in plasma, BALF and lung tissue were significantly decreased, while the contents of CD and MDA were significantly increased and MDA / And was significantly correlated with the increase of neutrophil count in BALF, suggesting that the imbalance of oxidation and anti-oxidant may play an important role in the development of acute smog lung injury