急性期反应包括局部和全身反应。即刻的局部反应包括单核细胞/巨噬细细的聚集和激活,这些细胞随后释放白细胞介素—1、肿瘤坏死因子和白细胞介素—6(IL—6),继后引起全身反应包括发热、白细胞增多等,并导致急性期蛋白合成增加。C-反应蛋白(CRP)是原型的人类急性期蛋白。已显示IL—6在人类急性期蛋白合成过程中起主要 Acute phase reactions include both local and systemic reactions. Immediate local reactions include monocyte / macrophage aggregation and activation, which subsequently release interleukin-1, tumor necrosis factor, and interleukin-6 (IL-6) followed by systemic reactions including fever , Leukocytosis, etc., and lead to increased protein synthesis in acute phase. C-reactive protein (CRP) is a prototype human acute phase protein. IL-6 has been shown to play a major role in human acute phase protein synthesis