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目的观察氨氯地平对老年高血压的治疗效果。方法本研究采用２４小时动态血压、超声心动图和平板运动检查，评价了氨氯地平对老年高血压患者左室肥厚和运动血压的影响。３６例按ＷＨＯ标准确诊为老年高血压者，排除继发性病因，停用降压药２周后给予氨氯地平５ｍｇ～７．５ｍｇ／ｄ，治疗四月。治疗前后行２４小时动态血压、超声心动图和平板运动试验检查。结果氨氯地平治疗后２４小时收缩压、舒张压及白昼、夜间收缩压、舒张压均明显低于治疗前；左室重量、室间隔厚度及左室后壁厚度亦明显减少；治疗后运动高峰时收缩压、运动停止后３分钟收缩压亦明显降低。结论氨氯地平能有效地降低老年高血压患者２４小时收缩压、舒张压，逆转心室肥厚，并明显降低患者运动时收缩压，但对运动时舒张压及血压昼夜节律无明显影响
Objective To observe the therapeutic effect of amlodipine on senile hypertension. Methods In this study, 24-hour ambulatory blood pressure, echocardiography and treadmill exercise tests were performed to evaluate the effect of amlodipine on left ventricular hypertrophy and exercise-induced hypertension in elderly hypertensive patients. Thirty-six cases were diagnosed as elderly hypertension according to the WHO standard, and secondary causes were excluded. After 2 weeks of antihypertensive treatment, amlodipine was given 5mg ~ 7.5mg / d for treatment of April. 24 hours before and after treatment of ambulatory blood pressure, echocardiography and treadmill exercise test. Results After 24 hours of amlodipine treatment, systolic blood pressure, diastolic blood pressure, systolic blood pressure at night and diastolic blood pressure at night were significantly lower than those before treatment; left ventricular mass, interventricular septum thickness and left ventricular posterior wall thickness were also significantly decreased; Systolic blood pressure, systolic blood pressure 3 minutes after the exercise stopped also significantly reduced. Conclusion Amlodipine can effectively reduce 24-hour systolic blood pressure, diastolic blood pressure, and reverse ventricular hypertrophy in elderly hypertensive patients, and significantly reduce systolic blood pressure during exercise, but have no significant effect on diastolic blood pressure and circadian blood pressure during exercise