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用HPLC法测定6名健康志愿者口服国产和进口卡马西平片后的药时曲线,结果表明两者无显著差异(p>0.05)。中国人体内卡马西平的生物半衰期为35.16±10.15h,与国外文献报道相似。
The pharmacokinetic profiles of domestic and imported carbamazepine tablets in six healthy volunteers were determined by HPLC. The results showed no significant difference (p> 0.05). The biological half-life of carbamazepine in Chinese was 35.16 ± 10.15h, similar to that reported in foreign literature.