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目的观察3种中医治法对胃癌前病变模型大鼠胃黏膜病理组织结构的影响。方法将60只Wistar大鼠随机分为正常对照组、模型对照组、健脾益气组、活血化瘀组和养阴荣络组,采用以化学损伤为主的综合法复制大鼠胃癌前病变模型,分别给予3种中药复方治疗6周,在光镜和电镜下比较胃黏膜组织形态学的变化。结果光镜下观察,3组中药均能在一定程度上减轻PLGC模型大鼠胃黏膜炎症;电镜下观察,3种中药都具有恢复PLGC模型大鼠胃黏膜细胞线粒体的作用。结论 3种治法方药可明显改善实验性大鼠胃癌前病变的胃黏膜炎症,修复受损伤的胃黏膜细胞,并存在有差异性,养阴荣络组的效果较为明显。
Objective To observe the effects of three kinds of traditional Chinese medicine (TCM) on gastric mucosa histopathology in rats with gastric precancerous lesion. Methods Sixty Wistar rats were randomly divided into normal control group, model control group, Jianpi Yiqi group, Huoxuehuayu group and Yangyinrongluo group. Model were given three kinds of traditional Chinese medicine compound for 6 weeks, under light and electron microscopy changes in gastric mucosal morphology. Results Under the light microscope, all the three Chinese herbs could alleviate the gastric mucosal inflammation in PLGC model rats to a certain extent. All the three Chinese herbs could restore the mitochondrial function of gastric mucosal cells in PLGC model rats under electron microscope. Conclusions The 3 prescriptions of traditional Chinese medicine can obviously improve the gastric mucosal inflammation in gastric precancerous lesions of rats and repair the damaged gastric mucosal cells. There are some differences between the two groups. The effect of Yangyin Rongluo Group is obvious.