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目的观察米索前列醇对产后出血的预防效果及安全性。方法选取具有产后出血高危因素的孕产妇197例,按照随机数字表法分为观察组99例,对照组98例。观察组胎前肩娩出后立即口服米索前列醇400μg。对照组胎前肩娩出后即静脉注射10%葡萄糖溶液20ml+缩宫素20U。出血量采用容积法和卫生纸称重法计算。结果观察组产后2h出血量(205.6±35.7)ml,对照组产后2h出血量(297.4±40.5)ml,观察组优于对照组,差异有统计学意义(P<0.05)。观察组发生产后出血1例(1.0%),对照组发生产后出血7例(7.1%),观察组优于对照组,差异有统计学意义(P<0.01)。结论米索前列醇预防产后出血疗效确切,使用方便,安全性高,是预防产后出血的较好方法,值得临床推广应用。
Objective To observe the preventive effect and safety of misoprostol on postpartum hemorrhage. Methods 197 pregnant women with risk factors for postpartum hemorrhage were selected and divided into observation group (n = 99) and control group (n = 98) according to random number table. The observation group received 400 μg of misoprostol immediately after delivery. The control group before delivery of fetal shoulder after intravenous injection of 10% glucose solution 20ml + oxytocin 20U. Bleeding volume method and toilet paper weighing method. Results The amount of bleeding at 2 hours postpartum was (205.6 ± 35.7) ml in control group and 297.4 ± 40.5 ml at 2 hours postpartum in control group. The difference was statistically significant (P <0.05). Postpartum hemorrhage was observed in 1 case (1.0%) in the observation group and in 7 cases (7.1%) in the control group. The observation group was superior to the control group with statistically significant difference (P <0.01). Conclusion Misoprostol is effective in preventing postpartum hemorrhage. It is easy to use and safe. It is a good way to prevent postpartum hemorrhage. It is worthy of clinical application.