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中华硬蜱雌性成虫再次感染家兔后，叮咬局部组织中组胺含量较初次感染显著升高（Ｐ＜０．０１）。为了进一步证实组胺在抗蜱免疫中的作用，本文选用苯海拉明（Ｈ１组胺受体拮抗剂）、盐酸雷尼替丁（Ｈ２组胺受体拮抗剂）给再次感染组家兔灌胃，观察使用组胺拮抗剂对中华硬蜱吸血、生殖能力的影响。结果显示：单独给予Ｈ１或Ｈ２受体拮抗剂不改变家兔获得性抵抗力，但同时给予Ｈ１和Ｈ２受体拮抗剂则可明显降低家兔的抗蜱免疫反应，从而使中华硬蜱吸血量、吸血时间、产卵量等较再次叮咬组家兔有显著变化（Ｐ＜０．０１）。
Histamine content in bite tissue was significantly higher than that in the first infection (P <0.01) after the female adult Ixodes sinensis infects the rabbits again. In order to further confirm the role of histamine in anti-tick immunity, we selected diphenhydramine (H1 histamine receptor antagonist) and ranitidine hydrochloride (H2 histamine receptor antagonist) to re-infected rabbits Stomach, to observe the effect of histamine antagonist on bloodsucking and reproductive capacity of Chinese Ixodes sinensis. The results showed that H1 or H2 receptor antagonist alone did not change the acquired resistance in rabbits, but the simultaneous administration of H1 and H2 receptor antagonists could significantly reduce the anti-tick immune response in rabbits, , Blood-sucking time, the number of spawning and so on were significantly different (P <0.01).