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目的 研究二甲双胍对老年非糖尿病性高血压肾脏的保护作用。方法 将患者分为硝苯地平及硝苯地平 +二甲双胍治疗二组 ,三个月后观察体重指数、血胰岛素、尿蛋白、尿素氮、血和尿 β2 微球蛋白的变化。结果 上述指标加二甲双胍组较单用硝苯地平组明显改善 (P <0 0 0 1)。结论 二甲双胍对老年高血压病的肾脏有保护作用。
Objective To study the protective effect of metformin on elderly non-diabetic hypertensive kidney. Methods The patients were divided into two groups: nifedipine and nifedipine + metformin. The changes of body mass index, blood insulin, urine protein, urea nitrogen, blood and urine β2 microglobulin were observed after three months. Results The above indexes plus metformin improved significantly compared with nifedipine alone (P <0.01). Conclusion Metformin has a protective effect on the elderly hypertensive kidney.