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观察不同程度缺氧ＳＤ大鼠（Ａ组：呼吸高峰减弱时刻，Ｂ组：首次端呼吸出现，Ｃ组：末次呼吸出现即缺氧耐受极限出现）的机能状态（呼吸、心率、紫绀）、缺氧耐受时间、大脑皮层电活动（诱发电位、脑电图），并进行急性重复缺氧实验。结果发现，Ａ组大鼠机能状态活跃，大脑皮层电活动逐次加强；Ｂ、Ｃ组大鼠机能状态、大脑皮层电活动逐次抑制，缺氧对Ｃ组大鼠机能状态、大脑皮层电活动的抑制程度比Ｂ组大鼠严重。Ａ组１～４次缺氧耐受时间之间无显著差异，Ｂ、Ｃ组大鼠缺氧耐受时间逐次递增，Ｃ组递增的幅度大于Ｂ组。第２、３、４次缺氧耐受时间Ａ组大鼠分别为第１次缺氧的１．０３、１．０３、１．０５倍；Ｂ组大鼠为１．２０、１．５０、２．１６倍；Ｃ组为１．４３、１．９１、２．７４倍。结果提示：大鼠急性缺氧耐受与中枢抑制有关，缺氧耐受性递增幅度与中枢抑制程度有关。
(Breathing, heart rate, cyanosis) were observed in hypoxia-deficient Sprague-Dawley rats with different degrees of hypoxia (group A: time of peak respiratory depression, group B: initial end respiration, group C: Hypoxia tolerance time, cerebral cortex electrical activity (evoked potentials, electroencephalogram), and acute repeated hypoxia experiments. The results showed that the functional status of group A was active and the electrical activity of the cerebral cortex increased step by step. The functional status of rats in group B and C were successively inhibited by electrical activity of the cerebral cortex, and the inhibitory effect of hypoxia on functional status and electrical activity of cerebral cortex The degree of serious than B rats. There was no significant difference in the duration of hypoxia between 1 and 4 times in group A, and the time of hypoxia tolerance in rats in groups B and C increased gradually. The increment in group C was greater than that in group B. The 2nd, 3rd and 4th hypoxia tolerance time of rats in group A were 1.03, 1.03 and 1.05 times that of the first hypoxia respectively; those in group B were 1.20 and 1.50, 2.16 times; C group was 1.43,1.91,2.74 times. The results suggest that acute hypoxia tolerance in rats is related to central inhibition, and the increasing extent of hypoxic tolerance is related to the degree of central inhibition.