论文部分内容阅读
目的:探讨HSG/MFN2和nm23在卵巢癌发生、发展过程中的作用及意义。方法:用免疫组化法检测HSG/MFN2和nm23在不同卵巢组织中的表达情况。结果:①HSG/MFN2阳性染色主要位于细胞浆,呈棕黄色颗粒,正常卵巢组织、良性卵巢肿瘤、恶性卵巢癌组,HSG/MFN2的阳性表达率分别为43.3%、46.7%和73.3%;与正常卵巢组织和良性卵巢肿瘤组比较,恶性卵巢癌组HSG/MFN2表达率呈上升趋势,差异均有统计学意义(P<0.05)。②nm23阳性染色主要位于细胞基质中,为棕黄色细颗粒。正常卵巢组织、良性卵巢肿瘤、恶性卵巢癌组nm23的阳性表达率分别为26.7%、43.3%和70.0%;与正常卵巢组织和良性卵巢肿瘤组比较,恶性卵巢癌组nm23表达率呈上升趋势,差异均有统计学意义(P<0.05)。结论:HSG/MFN2和nm23在恶性卵巢癌组织中表达上调,与卵巢癌淋巴结转移和临床病理分期密切相关,nm23蛋白低表达的卵巢癌发生转移的危险性高,提示nm23能显著抑制肿瘤转移。
Objective: To investigate the role and significance of HSG / MFN2 and nm23 in the development and progression of ovarian cancer. Methods: Immunohistochemistry was used to detect the expression of HSG / MFN2 and nm23 in different ovarian tissues. Results: ① HSG / MFN2 positive staining was mainly in cytoplasm with brownish yellow granules. The positive rates of HSG / MFN2 in normal ovarian tissue, benign ovarian tumor and malignant ovarian cancer group were 43.3%, 46.7% and 73.3% Compared with benign ovarian tumor, the expression of HSG / MFN2 in malignant ovarian cancer showed an upward trend, with significant difference (P <0.05). ② nm23 positive staining is mainly located in the cell matrix, as brown yellow fine particles. The positive rates of nm23 in normal ovarian tissue, benign ovarian tumor and malignant ovarian cancer group were 26.7%, 43.3% and 70.0%, respectively. Compared with normal ovarian tissue and benign ovarian tumor group, the expression rate of nm23 in malignant ovarian cancer group showed an upward trend, The differences were statistically significant (P <0.05). Conclusion: The upregulation of HSG / MFN2 and nm23 in malignant ovarian cancer tissues is closely related to lymph node metastasis and clinicopathologic stage of ovarian cancer. The high risk of metastasis of nm23 low ovarian cancer suggests that nm23 can significantly inhibit tumor metastasis.