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红细胞经胰蛋白酶处理后,海南株恶性疟原虫(Fcc-1/HN)裂殖子入侵明显抑制,经神经氮酸酶和麦胚凝集素(WGA)处理后裂殖子入侵受到部分抑制,而植物凝集素(PHA)处理对裂殖子入侵没有影响。经二酰胺(Diamide)、秋水仙碱和马来酰亚胺(NEM)处理的红细胞,裂殖子的入侵均受到显著抑制,以NEM的作用最强,当其浓度为2mM时,裂殖子的入侵完全被抑制。结果表明,应用化学与酶修饰的方法改变红细胞膜表面及膜骨架蛋白的结构和性质,恶性疟原虫裂殖子对红细胞的入侵作用出现变化。
After the erythrocytes were treated with trypsin, the invasion of macaque falciparum (Fcc-1 / HN) in Hainan strain was significantly inhibited, and the invasion of merozoites was partially inhibited by the treatment of NAC and WGA Plant lectin (PHA) treatment had no effect on merozoite invasion. The invasion of merozoites was significantly inhibited by diamide, colchicine and NEM-treated erythrocytes, and NEM was the strongest. When the concentration was 2mM, merozoites The invasion is completely suppressed. The results showed that the chemical and enzymatic modification methods changed the structure and properties of erythrocyte membrane surface and membrane scaffold proteins, and the invasion of erythrocytes by Plasmodium falciparum merozoites changed.