遗传性球形红细胞增多症(简称 HS)是一种少见的疾病。10岁以上病人中合并胆石症者约占半数。我们于1991年4月发现一家二代6人中,4人患 HS 并均合有胆石症,报告如下。首证例:女,32岁,住院号59585。因间断性上腹痛伴贫血、黄疸和轻度脾肿大2年余, Hereditary spherocytosis (referred to as HS) is a rare disease. About 10% of patients with cholelithiasis accounted for about half. We found in April 1991 a second generation of 6 people, 4 people suffering from HS and cholelithiasis, report as follows. The first card cases: female, 32 years old, hospital number 59585. Due to intermittent upper abdominal pain with anemia, jaundice and mild splenomegaly more than 2 years,