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目的:评价血清心脏特异性肌钙蛋白T(cTnT)定量测定以及肿瘤坏死因子(TNF)对不同程度心功能障碍患者心肌损伤的诊断价值.方法:对51例不同程度心功能障碍患者及25例健康人分别采用链霉系和包被一步法测定血清cTnT,肌酸激酶同工酶(CK－MB)试剂盒测定CK－MB和双抗体夹心ELISA法测定TNF.结果:患者组cTnT、CK－MB、TNF均高于对照组(P＜0.001).心功能IV级患者cTnT、CK－MB、TNF高于心功能Ⅲ级患者.同时5l例心功能障碍患者中有47例cTnT阳性,占92.16％,CK－MB仅14例阳性,占27.45％,直线相关分析表明cTnT与TNF呈正相关.结论:cTnT是反映心肌损伤的灵敏性和特异性较高的生化指标,TNF参与了心肌损伤过程、二者测值增高可作为判断心肌损伤的辅助指标.“,”Objective: For evaluating diagnostic value of serum cardiac specific troponin T(cT-nT) and tumor necrosis factor (TNF) on myocardial injury of the grades of cardiac dysfunction.Method:cTnT,creatine kinase isoenzyme MB(Ck-MB) and TNF in serum of 51 cases patients whohad different classes cardiac dysfunction and 25 cases normal persons were determined. Result:ThecTnT,CK-MB,TNF levels of patients\'group we higher than those of normal group (P <0.001).The cTnT,CK-MB, TNF of class IV cardiac function patients were higher than those of Ⅲ class.For cTnT, 47 cases of 5l patients were positive (92. 15% ),for CK-MB,only 14 cases were posi-tive, (27. 45% ). cTnT was correlated to TNF positively by linear regression analysis. Conclusion:cTnT is a better biochemical index for myocardial injury. TNF takes part in the process of myocar-dial injury. When the values of cTnT and TNF increase, they maybe used as auxiliary index for di-agnosis of myocardial injury.