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为了解单采浆供血员庚型肝炎病毒（ＨＧＶ）感染及其转归，对１０２名抗－ＨＣＶ阳性单采浆供血员冻存血清进行抗－ＨＧＶ和ＨＧＶＲＮＡ检测，对抗－ＨＧＶ和（或）ＨＧＶＲＮＡ阳性者作３年随访研究。采用ＥＩＡ法检测抗－ＨＧＶ，包被抗原来自ＨＧＶ不同功能区的合成肽。应用ＲＴ－ＰＣＲ法检测ＨＧＶＲＮＡ，引物选自ＨＧＶＮＳ３区。结果表明，抗－ＨＣＶ阳性单采浆供血员ＨＧＶＲＮＡ阳性率为１９．６１％（２０／１０２），抗－ＨＧＶ阳性率为１７．６５％（１８／１０２），ＨＧＶ感染率（抗ＨＧＶ和／或ＨＧＶＲＮＡ阳性）为２４．５１％（２５／１０２），而对照组仅为０．９４％（１／１０６）。提示单采血浆是ＨＧＶ感染的重要危险因素。ＨＧＶＲＮＡ和抗－ＨＧＶ的３年阴转率分别为３５．００％（７／２０）和１１．１１％（２／１８），说明ＨＧＶ感染有慢性携带趋势
In order to understand the prevalence of hepatitis G virus (HPG) infection and its prognosis in 102 plasma monolayer blood donors, anti-HGV and HGV RNA were detected in 102 cryopreserved anti-HCV positive monophasic blood donors, anti-HGV and / HGV RNA positive for 3 years follow-up study. Anti-HGV was detected by EIA and the synthetic peptides from different functional regions of HGV were coated with antigens. The HGV RNA was detected by RT-PCR and the primers were selected from the HGVNS3 region. The results showed that the positive rate of anti-HCV positive plasma was 19.61% (20/102), anti-HGV positive rate was 17.65% (18/102), and the positive rate of HGV infection (anti-HGV and / Or HGV RNA positive) was 24.51% (25/102), while the control group was only 0.94% (1/106). Tip apheresis plasma HGV infection is an important risk factor. The 3-year overcast rates of HGVRNA and anti-HGV were 35.00% (7/20) and 11.11% (2/18), respectively, indicating a trend of chronic carriers of HGV infection