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用细胞内微电板方法研究低浓度非洛地平对豚鼠右心室乳头肌动作电位的作用。非洛地平０．１，１ｎｍｏｌ·Ｌ－１对动作电位无作用。但在５ｎｍｏｌ·Ｌ－１时，非洛地平可明显延长动作电位时程。延长作用的起效时间为５ｍｉｎ，作用持续６０ｍｉｎ以上。用台氏液冲洗可使非洛地平的延长作用消失。非洛地平５ｎｍｏｌ·Ｌ－１和３μｍｏｌ·Ｌ－１对动作电位时程具有低浓度延长，高浓度缩短的双相作用。硝苯地平１ｎｍｏｌ·Ｌ－１可明显延长动作电位时程，但维拉帕米０．１．１和５ｎｍｏｌ·Ｌ－１对动作电位无明显作用。这表明低浓度激动心肌钙通遁可能是二氢吮嚏矣钙拮抗剂的共性，但不是所有钙拮抗剂的共性。
Effect of Low Concentration Felodipine on Action Potential of Guinea Pig Papillary Muscles in Guinea Pigs Using Intracellular Microelectrode Method. Felodipine 0.1,1 nmol·L-1 had no effect on action potential. However, at 5 nmol·L-1, felodipine significantly prolonged the action potential duration. Prolonged effect of the onset time of 5min, the role of sustained 60min or more. Flush with Tyrode’s solution can make felodipine extension disappear. Felodipine 5nmol·L-1 and 3μmol·L-1 had a biphasic effect on action potential duration with low concentration and shortened concentration. Nifedipine 1nmol·L-1 can significantly prolong the action potential duration, but verapamil 0.1.1 and 5nmol·L-1 on the action potential had no significant effect. This suggests that low concentrations of stimulated calcium channel escape may be dihydrogen sufferers calcium antagonist commonality, but not all calcium antagonist commonality.