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目的探讨胃肠道间质瘤(GIST)临床特点及诊断治疗。方法回顾性分析2007年10月—2010年3月收治的21例GIST患者的临床资料。结果 21例GIST均经病理等检查证实为良性间质瘤10例,恶性8例,交界性3例。肿瘤大小与良恶性相关。全部病例均行外科手术切除,无手术并发症及手术死亡病例。结论 CD117和CD34阳性表达是诊断GIST最可靠的辅助指标。外科手术和分子靶向治疗是GIST的主要治疗手段。
Objective To investigate the clinical features and diagnosis and treatment of gastrointestinal stromal tumors (GIST). Methods The clinical data of 21 patients with GIST admitted from October 2007 to March 2010 were retrospectively analyzed. Results 21 cases of GIST were pathologically confirmed as benign stromal tumors in 10 cases, 8 cases of malignancy, borderline in 3 cases. Tumor size is related to benign and malignant tumors. All patients underwent surgical resection, no surgical complications and surgical deaths. Conclusions The positive expression of CD117 and CD34 are the most reliable auxiliary indicators for the diagnosis of GIST. Surgical and molecular targeted therapies are the mainstay of treatment for GIST.