椎间盘退变常会引起腰背痛。长期以来人们对椎间盘退变机制进行了大量的探索与研究,目前普遍认为椎间盘退变是一个多因素诱导的(遗传因素、环境因素、年龄因素)、多种因子(生长因子、炎性因子)参与的不可逆的过程,其确切机制尚不明确。模型的建立可与退变机制的研究相互论证, Disc degeneration often cause low back pain. For a long time people have made a great deal of exploration and research on the mechanism of disc degeneration. At present it is generally accepted that disc degeneration is a multifactorial factor (genetic factor, environmental factor, age factor), and many factors (growth factor, inflammatory factor) The exact mechanism of participation in the irreversible process is not yet clear. The establishment of the model can be argued with the study of degeneration mechanism,