佐剂是现代疫苗开发的重要一环。尽管佐剂有着数十年的发展历程,但当前仅有少数几种类型的佐剂能够用于人用疫苗。为了更好地理解有些佐剂能够成功应用而另一些被舍弃的原因,我们会讨论几种成功应用的第一代佐剂的共同属性。接下来,将评估第二代佐剂的当前发展趋势,包括设计合理、配方适宜的合成免疫增强剂所具有的潜在优势。最后,讨论下一代佐剂值得具有的属性。自始至终,都 Adjuvants are an important part of modern vaccine development. Although adjuvants have decades of development, only a few types of adjuvants are currently available for human vaccines. To better understand why some adjuvants are successfully applied and others are discarded, we discuss the common attributes of several successful first-generation adjuvants. Next, current trends in second-generation adjuvants will be evaluated, including the potential benefits of well-designed, well-formulated synthetic immunostimulants. Finally, discuss the properties worthy of the next generation of adjuvants. From start to finish, all