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目的:探讨表皮生长因子受体(EGFR)在宫颈炎症组织、宫颈上皮内瘤变(CIN)和宫颈浸润性鳞状细胞癌中的表达变化及意义。方法:收集2013-2014年河源市人民医院经病理确诊的宫颈活检标本和手术标本共101例患者,采用免疫组织化学技术检测EGFR在18例宫颈炎症组织、48例CIN、13例CINⅠ级、15例CINⅡ级、20例CINⅢ级、35例宫颈浸润性鳞状细胞癌的表达情况。结果:EGFR在上述各组的表达率依次为5.56%(1/18)、47.91%(23/48)、23.08%(3/13)、46.67%(7/15)、65%(13/20)、62.86%(22/35),CIN组、CINⅡ组、CINⅢ组、鳞癌组与炎症组比较,差异具有统计学意义(P<0.05)。CINⅠ组与CINⅢ组及鳞癌组比较,差异具有统计学意义(P<0.05),CINⅠ组与炎症组、CINⅠ组与CINⅡ组、CINⅡ组与CINⅢ组、CINⅢ组与鳞癌组比较,差异无统计学意义(P>0.05)。结论:EGFR的表达与CIN的进展过程及宫颈癌的进展过程紧密相关,可能参与了宫颈癌病变发生发展的全过程,可作为宫颈癌诊断及预后的参考指标。
Objective: To investigate the changes and significance of epidermal growth factor receptor (EGFR) in cervical inflammation, cervical intraepithelial neoplasia (CIN) and cervical invasive squamous cell carcinoma. Methods: A total of 101 cervical biopsy specimens and surgical specimens confirmed by pathology from 2013 to 2014 in Heyuan People’s Hospital were collected. The expression of EGFR in 18 cases of cervical inflammation, 48 cases of CIN, 13 cases of CINⅠ, Cases of CIN Ⅱ grade, 20 cases of CIN Ⅲ grade, 35 cases of invasive cervical squamous cell carcinoma of the expression. Results: The expression rates of EGFR in the above groups were 5.56% (1/18), 47.91% (23/48), 23.08% (3/13), 46.67% (7/15), 65% ), 62.86% (22/35), CIN group, CINⅡgroup, CINⅢgroup, squamous cell carcinoma group and inflammation group respectively. The difference was statistically significant (P <0.05). The difference was statistically significant between CINⅠgroup and CINⅢgroup and squamous cell carcinoma group (P <0.05). There was no significant difference between CINⅠgroup and inflammation group, CINⅠgroup and CINⅡgroup, CINⅡgroup and CINⅢgroup, CINⅢgroup and squamous cell carcinoma group Statistical significance (P> 0.05). Conclusion: The expression of EGFR is closely related to the progress of CIN and the progression of cervical cancer, which may be involved in the whole process of cervical cancer. It may serve as a reference index for the diagnosis and prognosis of cervical cancer.