恶性细胞有别于正常细胞的显著特征之一,在于它们具有浸润性。1925年Fischer最早研究恶性细胞的体外浸润能力。之后,不少研究者应用不同的培养系统也都观察到恶性细胞的这种特征。Abercrombie认为,恶性细胞运动的接触抑制缺陷与浸润性有关。近几年来,我国细胞生物学研究者曾相继建立了不少长期培养的人癌细胞系。这些细胞系是否皆丧失了运动的接触抑制特性?它们是否仍 One of the salient features that malignant cells distinguish from normal cells is that they are infiltrating. 1925 Fischer earliest study of malignant cells in vitro invasive ability. Since then, many researchers have observed this characteristic of malignant cells using different culture systems. Abercrombie believes that contact inhibition of malignant cell movement and infiltration of defects related. In recent years, China’s cell biology researchers have successively established a lot of long-term human cancer cell lines. Are these cell lines losing contact inhibition of exercise? Are they still