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目的探讨干扰素在治疗小儿喘息性支气管炎中对免疫系统调节机制及临床疗效,进一步阐述本病的发病机制与影响因素,为临床更好的诊断与治疗提供客观的依据和参考。方法将我院2010年1月—2013年10月儿科住院治疗的小儿喘息性支气管炎60例,随机分为对照组30例(常规治疗);观察组30例(常规治疗+干扰素治疗),比较两组患儿治疗后疗效。结果两组患儿治疗后外周血WBC、嗜酸性粒细胞、白细胞介素(IL-2、4、5)水平比较具有显著性差异(P<0.05);两组患儿治疗后疗效比较具有显著性差异(P<0.05)。结论干扰素可有效干预患儿WBC、嗜酸性粒细胞、IL-2、IL-4、IL-5水平,缩短患儿治疗时间。
Objective To investigate the regulatory mechanism and clinical efficacy of interferon in the treatment of infantile asthmatic bronchitis and further elucidate the pathogenesis and influencing factors of this disease and provide an objective basis and reference for better clinical diagnosis and treatment. Methods Sixty children with asthmatic bronchitis admitted to our hospital from January 2010 to October 2013 were randomly divided into control group (30 cases) and control group (30 cases) The therapeutic effects of two groups were compared. Results The levels of WBC, eosinophils and interleukin (IL-2, 4, 5) in peripheral blood of two groups of children after treatment were significantly different (P <0.05). The therapeutic effects of two groups of children after treatment were significant Sex differences (P <0.05). Conclusion Interferon can effectively interfere with the levels of WBC, eosinophils, IL-2, IL-4 and IL-5 in children and shorten the treatment time in children.