目的评价初次小梁切除术后结膜下注射５－氟尿嘧啶的作用与安全性。方法原发性闭角型青光眼接受初次小梁切除术１６例，作为治疗组于术后第一天开始接受结膜下５－Ｆｕ注射，每次５ｍｇ，共１０次。对照组１６例未接受结膜下注射。结果术前眼内压两组间差异无显著性。出院时眼内压治疗组１６０±０８９ｋＰａ，对照组２５３±１３０ｋＰａ（Ｐ＜００５）。最后一次随访治疗组眼内压（２７３±１００）ｋＰａ，对照组眼内压（３４７±１０３）ｋＰａ（Ｐ＜００５）。功能滤过泡形成率，治疗组７５％，对照组３７５％（Ｐ＜００５）。并发症两组间无差异。结论：５－Ｆｕ可提高初次小梁切除术的成功率，降低术后眼内压水平，不引起明显的并发症 Objective To evaluate the effect and safety of subconjunctival 5-fluorouracil injection after primary trabeculectomy. Methods Primary primary angle-closure glaucoma underwent primary trabeculectomy in 16 cases. As the treatment group, subconjunctival 5-Fu injection was started on the first postoperative day for 5 times each for 10 times. Control group, 16 patients did not receive subconjunctival injection. Results preoperative intraocular pressure was no significant difference between the two groups. On discharge, IOP was 1.60 ± 0.89 kPa in the IOP group and 2.53 ± 1.30 kPa in the control group (P <005). The last follow-up treatment group intraocular pressure (2  73 ± 1  00) kPa, the control group intraocular pressure (3  47 ± 1  03) kPa (P  0  05). The rate of formation of functional bleb was 75% in the treatment group and 37.5% in the control group (P <005). Complications between the two groups no difference. Conclusion: 5-Fu can improve the success rate of primary trabeculectomy, reduce the level of intraocular pressure after surgery without causing obvious complications