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通过对附子生物碱进行脱毒处理,将双酯型附子生物碱水解为单酯型附子生物碱,分别测定了脱毒前后附子生物碱对小菜蛾的室内毒力活性,包括拒食活性、胃毒活性和生长抑制活性.拒食活性中,非选择性拒食率脱毒前后的毒力回归曲线分别为y=-3.312+2.014X,y=-1.666+1.716X,AFC50分别为0.651和0.971 g/L.选择性拒食率的毒力回归曲线分别为y=-0.859+1.141X,y=-1.718+1.431X,AFC50为0.753和1.201 g/L.胃毒活性中,死亡率的毒力回归曲线分别为y=-1.296+1.838X,y=-1.386+1.379X,LC50分别为0.705和1.005 g/L.生长抑制活性中,生长抑制率的毒力回归曲线分别为y=-1.283+1.73X,y=-1.24+1.316X,AGC50分别为0.742和0.942 g/L.分析以上三种活性可知,脱毒前附子生物碱对小菜蛾的杀虫活性主要体现在拒食活性上,其次为生长抑制活性和胃毒活性;脱毒后杀虫活性有所降低,但未全部丧失,尤其在拒食活性上表现明显.“,”Based on the detoxification treatment,making the double ester type of aconite alkaloids hydrolyzed single ester type,we have determined the antifeedant activity,stomach toxicity and growth inhibitory activity by the aconite alkaloids before and after partial detoxification.For the antifeedant activity,the regression curve of the non selective antifeedant rate before and after detoxification is y =-3.312 +2.014X,y =-1.666 +1.716X,with AFC50 equal to 0.651 and 0.971 g/L,respectively.The regression curve of the selective antifeedant rate is y =-0.859 +1.141X,y =-1.718 +1.431X,with AFC500.753 and 1.201 g/L,respectively.For the gastric tox-icity,the regression curve of mortality is y =-1.296 +1.838X,y =-1.386 +1.379X,with LC50 as 0.705 and 1.005 g/L,respectively.For the growth inhibition activity,the growth inhibition rate of the regression curve is y =-1.283 +1.73X,y =-1.24 +1.316X,with AGC50 to be 0.742 and 0.942 g/L,respectively.It can be seen from above results about the three kinds of activity that aconite alkaloids has a strong insecticidal effect before detoxification,which is mainly reflected by the antifeedant inhibition followed by the gastric toxicity.The activity is markedly reduced after detoxification,though not all of it is completely diminished,especially for the antifeedant activity.