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Objective: To explore the effect of curcumin on PKR signal and immune function in sepsis-infected lung injury rats. Methods: Set 15 spf-grade SD rats as sham operation group (Sham group), model group (ALI group) and curcumin group (curcumin group). The lung injury model of sepsis infection was established in the latter two groups. Only the distal end of the cecum was separated in the abdomen of the Sham group. The saline intervention was performed in the Sham group after surgery. Injection; Curcumin group was injected intraperitoneally with 200 mg of curcumin 2 h after surgery. Hematoxylin staining to observe pathology, multiple kits to detect cytokines, kits were used to detect lung tissue MDA, SOD, GSH-Px, CAT, F-800 blood cell counter was used to detect immune function, and immunoblot was used to detect PKR protein. Results: The lung bubbles in the Sham group were clear, and there was no inflammatory infiltration in the interstitial space. In the ALI group, the widened interstitial lung had severe inflammation, some alveolar rupture, and intracavitary hemorrhage. Compared with the ALI group, the curcumin group had less inflammation and increased interstitial width. Lung tissue damage improved; The levels of cytokines in the ALI group were lower than in the previous group (P <0.05). The curcumin group was lower than the ALI group (P <0.05); the levels of immune function cells were not similar in the ALI combination (P <0.05), and the curcumin group was not similar to the ALI group (P <0.05); oxidative stress indicators levels in ALI group The levels of these factors were different from those in the Sham group (P <0.05). The levels of the above factors in the curcumin group were different from those in the ALI group (P <0.05). The PKR protein level in the lung tissue of the ALI group was lower than the relative PKR protein level in the Sham group (P <0.05). The PKR protein level in the curcumin group was higher than that in the ALI group (P <0.05). Conclusion:Curcumin can improve the immune function of ALI rats with sepsis infection and reduce serum inflammation expression in model rats, which may be related to increasing PKR protein level.