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目的:制备盐酸伊立替康脂质体并考察提高脂质体稳定性的方法。方法:采用硫酸铵梯度法制备盐酸伊立替康脂质体。以粒径、外观、颜色、渗漏率作为指标,考察盐酸伊立替康脂质体的物理和化学稳定性。结果:硫酸铵梯度法制备的盐酸伊立替康脂质体呈圆球形,平均粒径为600nm,稳定性较好。结论:盐酸伊立替康脂质体不耐高温,将其制成冻干粉剂可显著提高药物稳定性。
OBJECTIVE: To prepare Irinotecan hydrochloride liposomes and investigate the method to improve the stability of liposomes. Methods: The irinotecan hydrochloride liposomes were prepared by ammonium sulfate gradient method. The physical and chemical stability of irinotecan hydrochloride liposomes were investigated with particle size, appearance, color and leakage rate as indexes. Results: The irinotecan hydrochloride liposomes prepared by ammonium sulfate gradient method were spherical, the average particle size was 600nm, and the stability was good. Conclusion: The irinotecan hydrochloride liposomes are not thermostable and their lyophilized powder can significantly improve the stability of the drug.