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硝苯吡啶(心痛定)为膜转移钙离子拮抗剂,被广泛用于治疗冠心病、心绞痛和高血压。近年来文献报道,本品可引起反常性心绞痛。有的用药后10～15分钟出现症状,表现为窒息性疼痛;有的二次用药,再次出现,停药后症状减轻。据认为硝苯吡啶在扩张冠动脉和增加冠状循环血液量的同时,能反射性地引起交感神经兴奋性增强,加快窦性节律,增加心肌耗氧量,诱发心绞痛。此时,由于硝苯吡啶能降低血压
Nifedipine (nifedipine) is a membrane -transfer calcium antagonist and is widely used in the treatment of coronary heart disease, angina, and hypertension. In recent years reported in the literature, this product can cause abnormal angina. Some symptoms after 10 to 15 minutes after treatment, manifested as asphyxia; some secondary medication, appear again, relieve symptoms after stopping. It is believed that nifedipine in the dilatation of the coronary artery and increase the amount of coronary blood circulation, reflex can cause sympathetic excitability increased, to accelerate sinus rhythm, increase myocardial oxygen consumption, induced angina. At this point, nifedipine can lower blood pressure