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颅内肿瘤在我国居民发病率为1.34/10万,脑胶质瘤约占颅内肿瘤的43%,可发生在中枢神经系统任何部位和任何年龄.恶性胶质瘤自然病程从出现症状至死亡平均时限约半年,六十年代常规治疗(手术加放疗)后的平均存活期不到一年,故提高恶性胶质瘤的疗效是神经外科领域亟需研究探讨的重大课题.胶质瘤的生物学特性是:(1)肿瘤呈浸润性生长,病理所见常比临床及放射学估计的范围更广泛,手术难以全切除;(2)肿瘤边缘正常脑细胞与肿瘤细胞交织处仍存在血脑屏障,
The incidence of intracranial tumors in China is 1.34 / 100000, gliomas account for about 43% of intracranial tumors, can occur in any part of the central nervous system and at any age. The natural history of malignant glioma from symptoms to death The average duration of about six months, the sixties of the conventional treatment (surgery plus radiotherapy) after the average survival of less than one year, so to improve the efficacy of malignant glioma is an urgent need to study the field of neurosurgery major issue to explore. Learning characteristics are: (1) tumor was invasive growth, pathological findings than clinical and radiological estimates of the broader scope of surgery is difficult to total resection; (2) the edge of the tumor normal brain cells and tumor cells still exist at the intersection of blood brain barrier,