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目的制备巴洛沙星胃内漂浮缓释片,并对其体外释药性能进行评价。方法以体外释放度试验为手段,通过单因素试验和正交试验设计考察并优化巴洛沙星胃内漂浮缓释片的处方及工艺,并对其释药机制进行初步研究。结果以巴洛沙星200 mg,CaCO340 mg,羟丙基甲基纤维素K4M/十八醇(1∶1)调节片质量至400 mg,硬度为10 kgf压片,所得片剂在15 min内起漂,且能维持8 h以上,药物释放曲线符合Hixson-Crowell溶蚀方程和Ritger-Peppas方程,以溶蚀机制为主。结论该制剂具有明显的漂浮和缓释性能,且工艺简单。
OBJECTIVE To prepare the gastric floating propofol tablets of barofloxacin and evaluate its in vitro drug release. Methods In vitro release test was used as a measure to investigate and optimize the formulation and process of the gastric floating propofol tablets by single factor test and orthogonal test. The release mechanism was also studied. Results The tablet quality was adjusted to 400 mg with barofloxacin 200 mg, CaCO3 40 mg, hydroxypropylmethylcellulose K4M / octadecanol (1: 1), and the hardness was 10 kgf. The tablets were obtained within 15 min From the bleaching, and can be maintained more than 8 h, the drug release curve in line with Hixson-Crowell dissolution equation and Ritger-Peppas equation, mainly to the dissolution mechanism. Conclusion The preparation has obvious floating and slow release properties, and the process is simple.