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目的研究孕妇外周血及胎盘组织中Annexin V变化与胎儿生长受限的关系。方法以本院住院分娩的孕妇为研究对象,在随机选取的125例患者中有60例出现胎儿生长受限的情况,而剩余65例为正常孕妇,将其分为FGR组和正常组进行研究,分别采用ELISA法及免疫组化染色法测量孕妇外周血及胎盘组织中的Annexin V含量变化。结果所选研究孕妇基本资料情况的比较差异不具有差异性;而经过两种方法对Annexin V进行测定后,FGR组中外周血与胎盘组织中的含量均要低于正常组中的含量,以上数据均在差异比较范围内。结论 Annexin V的变化与胎儿生长受限的存在着一定的相关性,可以以此对胎儿的生长发育情况进行预测,并进行相应的干预。
Objective To study the relationship between the changes of Annexin V in peripheral blood and placenta of pregnant women and fetal growth restriction. Methods In-hospital delivery of pregnant women as the research object, randomly selected in 125 patients, 60 cases of fetal growth restriction, and the remaining 65 cases of normal pregnant women, will be divided into FGR group and normal group The changes of Annexin V in peripheral blood and placenta of pregnant women were measured by ELISA and immunohistochemical staining respectively. Results There was no difference in the basic information of selected pregnant women; however, after the two methods were used to determine Annexin V, the content of peripheral blood and placental tissue in FGR group was lower than that in normal group, The data are in the range of difference comparison. Conclusions The change of Annexin V is related to the existence of fetal growth restriction. It can be used to predict the growth and development of the fetus and to make corresponding interventions.