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目的：探讨虎杖膏对急性闭合性软组织损伤(Closed soft tissue injury ,STI)消肿的应用效果。方法选用由遵义医学院实验动物中心提供健康成年大白兔18只，根据研究目的按敷药时间设计敷药24 h、48 h和72 h 3种用药方案，每种方案采用自身对照的方式设置实验组和对照组，即每只兔子一侧大腿作实验组，另一侧大腿作对照组，观察兔子肢体肿胀值、皮肤颜色、出血点、皮下瘀斑、进食及排泄情况。结果肢体肿胀值在敷药48 h组的实验组与对照组比较各观察时间点均有统计学差异（P<0.05），敷药24h组和敷药72h组均在4h和72h两个时间点有统计学差异（P<0.05），虎杖膏外敷24h组和外敷48h组在12h和24h两个时间点有统计学差异（P＜0.05）；实验组和对照组的皮肤颜色、出血点以及皮下瘀斑在各时间点比较差异均无统计学意义（P＞0.05）；敷药48h组有1只兔子死亡，72h组3只兔子死亡。结论急性闭合性软组织损伤早期采用虎杖膏外敷治疗具有显著消肿效果，但是需要严格控制敷药时间。“,”Objective To investigate the effect of giant knotweed cream in treating acute closed soft tissue injury. Methods Provided by the Zunyi Medical Experimental Animal Center ,According medication time 18 healthy adult rabbits were divided into three groups,namely, 24h, 48h and 72h group,N=6. Self-control ed manner was used, rabbit’s thigh on one side is the experimental group, and on the other side is the control group, skin color and swel ing, bleeding, ecchymosis, eating and excretion were al observed. Results Limb swel ing in the treated group of 48 h the experimental group compared with the control group there were signiifcant differences at each observation time point(P<0.05), 24h and 72h treated groups were treated in the 4H and 72h have two points in time difference (P<0.05), polygonum cuspidatum plaster external application of 24h and 48h in 12h and 24h have two points in time difference (P0.05);48h medicinal paste group had a rabbit died, 72h medicinal paste group 3 died. Conclusion Acute closed soft tissue injury take giant knotweed cream treatment has signiifcant effect,but the medicinal paste time should be control ed strictly.