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目的了解深圳市某社区2012年成人及健康儿童手足口病隐性感染情况,探讨肠道病毒隐性感染在儿童手足口病(HFMD)中的危害性。方法在该社区健康人群中随机选取不同年龄层个体,酶联免疫法检测血清中抗肠道病毒71型(EV71)和柯萨奇病毒A16型(CoxA16)的IgG抗体水平;同时进行粪便标本肠道病毒通用型、肠道病毒71型(EV71)、柯萨奇A16型(CA16)核酸检测。结果抗EV71和CoxA16 IgG抗体的阳性率随年龄增长,先上升后下降,5～岁儿童组的抗EV71IgG和抗CoxA16 IgG抗体阳性率最高,粪便样本中EV通用型阳性16.67%,5岁以下85.0%。CA16阳性3份,EV71阳性2份,均属于0～岁组。结论人群对EV71和CoxA16普遍易感,5岁以内儿童为主要感染人群,感染以后能产生特异性免疫力。肠道病毒在人群中隐形感染较为普遍,但健康人群中引起手足口病常见的EV71和CA16亚型隐性感染率低。
Objective To investigate the prevalence of hand-foot-mouth disease (HIFD) in adults and healthy children in a community in Shenzhen in 2012 and to explore the dangers of HID in patients with hand-foot-mouth disease (HFMD) in children. Methods Serum levels of IgG antibodies against enterovirus 71 (EV71) and Coxsackie virus A16 (CoxA16) were detected by enzyme-linked immunosorbent assay (ELISA) in randomly selected healthy individuals of this community. Simultaneously, Universal virus, Enterovirus 71 (EV71), Coxsackie A16 type (CA16) nucleic acid detection. Results The positive rate of anti-EV71 and CoxA16 IgG antibody increased with age at first, then increased and then decreased. The positive rates of anti-EV71 IgG and anti-CoxA16 IgG in children aged 5 to 6 years were the highest, positive EV 16.67% in stool samples and 85.0 %. CA16 positive 3, EV71 positive 2, belong to 0 ~ group. Conclusion The population is generally susceptible to EV71 and CoxA16, and children within 5 years of age are the major infectious groups, which can produce specific immunity after infection. Intestinal virus invisible in the crowd is more common, but in healthy people common cause of hand-foot-mouth disease EV71 and CA16 subtypes low latent infection.