慢性鼻-鼻窦炎作为耳鼻喉科常见病,其发病机制并不很清楚。在患者的分泌物及其黏膜下经常会见到免疫球蛋白E(IgE)。IgE通常被认为在过敏的个体中出现较多,然而,研究发现,在鼻-鼻窦炎的发生过程中,同样有他(IgE)的参与。这一发现引起人们对IgE的重视,下面我们就免疫球蛋白E在鼻-鼻窦炎发病机制中的作用做一综述。 Chronic rhinosinusitis, as a common disease of otolaryngology, the pathogenesis is not very clear. Immunoglobulin E (IgE) is frequently seen in patients with secretions and their submucosa. IgE is generally considered to occur more frequently in individuals with allergies. However, studies have found that IgE also participates in the pathogenesis of rhinosinusitis. This discovery arouses people’s attention on IgE. Here we review the role of immunoglobulin E in the pathogenesis of rhinosinusitis.