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目的研究肝硬化失代偿门静脉血栓(PVT)形成与凝血异常关系。方法选取肝硬化失代偿期患者131例，其中21例肝硬化失代偿期合并PVT患者作为PVT组，110例肝硬化失代偿期无PVT患者作为非PVT组。分析患者年龄、性别、肝硬化病因、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、国际标准化比值(INR)、纤维蛋白原(Fib)等相关检查资料。计量资料采用采用检验，绘制ROC曲线计算AUC，判断各指标的诊断价值。结果 PVT组与非PVT组性别、年龄、病因无统计学差异(>0.05)。PVT组的PT、INR、APTT较非PVT组明显缩短，各项差异均有统计学意义(INR>PT。结论血浆纤维蛋白原升高及血液相对高凝状态是肝硬化失代偿期患者PVT形成的危险因素。“,”Objective To explore the relationship between portal venous thrombosis (PVT) and abnormal coagulation function in the decompensated cirrhosis. Methods 131patients with the decompensated cirrhosis were involved in this study,including 21 with PVT as PVT group and 110 without PVT as none-PVT group.Relative data on the age,gender,etiology,PT,APTT,INR,Fib and etc of these patients were assessed via t-test as well as AUC under the ROC curve. Results Compared with none-PVT group,the PT、INR、APTT of PVT group are lower but its Fib is higher ,with 0.05.The predicted values resulting from AUC under the ROC curve are as follow:Fib (0.768)>APTT (0.273)>INR (0.209)>PT (0.196).Conclusion The increased Fib and relative hypercoagulability are risk factors for PVT in the patients with the decompensated cirrhosis.