论文部分内容阅读
AIM:The present study evaluated the cardioprotective property of the hydroethanol extract of Urtica parviflora leaf material(EEUP) against doxorubicin-induced cardiotoxicity in rats.METHODS:Cardiotoxicity was produced by doxorubicin ad-ministration(15 mg·kg-1 i.p.for 21 days).The rats received EEUP at 200 and 400 mg?kg-1 b.w.(i.p.) daily for 21 days.After 24 h,serum cardiac biomarkers,i.e.creatine phosphokinase(CPK) and lactate dehydrogenase(LDH);serum lipid profiles,like high density lipoprotein(HDL),low density lipoprotein(LDL) and triglyceride(TG);serum biochemical parameters,viz.aspartate aminotransferase(AST),alanine transaminase(ALT) and alkaline phosphatase(ALP);myocardial antioxidant parameters,viz.malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT) and reduced glutathione(GSH) were measured.RESULTS:EEUP treatment significantly(P < 0.01) and dose dependently protected the myocardium by decreasing the elevated level of MDA;elevating the diminished levels of GSH,SOD,CAT and HDL,with a concomitant decrease in the elevated levels of HDL,LDL,and TG.EEUP also significantly(P < 0.01) reduced the increased activities of AST,ALT,ALP,CPK and LDH.The results revealed that EEUP demonstrated dose dependent cardioprotective efficacy by restoration of the serum biomarkers profile and antioxidant property.CONCLUSION:From the present study,U.parviflora leaf extract showed promising cardioprotective effect against doxorubicin-induced cardiotoxicity in Wistar rats.
AIM: The present study evaluating the cardioprotective property of the hydroethanol extract of Urtica parviflora leaf material (EEUP) against doxorubicin-induced cardiotoxicity in rats. METHODS: Cardiotoxicity was produced by doxorubicin ad-ministration (15 mg · kg -1 ipfor 21 days ). The rats received EEUP at 200 and 400 mg? Kg-1 bw (ip) daily for 21 days. After 24 h, serum cardiac biomarkers, iecreatine phosphokinase (CPK) and lactate dehydrogenase high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG); serum biochemical parameters, viz.aspartate aminotransferase (AST), alanine transaminase (ALT) and alkaline phosphatase (P <0.01) and dose dependently protected the myocardium by decreasing the elevated level of MDA; elevating the diminished content of MDA; superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) levels of GSH, SOD, CAT and HDL, with a concomitant decrease in the elevated levels of HDL, LDL, and TG.EEUP also significantly (P <0.01) reduced the increased activities of AST, ALT, ALP, CPK and LDH.The results revealed that EEUP demonstrated dose dependent cardioprotective efficacy by restoration of the serum biomarkers profile and antioxidant property. CONCLUSION: From the present study, U. parviflora leaf extract showed promising cardioprotective effect against doxorubicin-induced cardiotoxicity in Wistar rats.