论文部分内容阅读
目的探讨中药离子透入对儿童难治性肾病的临床效果及作用机制。方法:将66例确诊患者按就诊顺序随机分为治疗组对照组。对照组给予常规以糖皮质激素联合其他免疫抑制剂治疗。治疗组在对照组治疗基础上辅以穴位透入治疗仪连接中药贴片贴敷于肾俞穴进行治疗,疗程均为半年,用药前后进行疗效比较并进行重复肾活检,应用Scion Imageβ软件进行病理变化分析。随访3年,记录复发情况。结果治疗组临床总有效率为97.1%,对照组为81.2%,总有效率明显优于对照组(P<0.05)。重复肾活检定量分析显示:治疗组肾小球指数(GI)显著降低,对照组增加,肾小管间质慢性化病变指数(TI)治疗组下降,对照组不变。间质病变指数(VI)治疗组不变,对照组下降。结论中药离子透入对儿童难治性肾病的临床疗效显著,并能明显改善肾脏病理改变,是一种有效治疗儿童难治性肾病的方法。
Objective To investigate the clinical effect and mechanism of iontophoresis of traditional Chinese medicine on intractable nephropathy in children. Methods: 66 cases of patients diagnosed were randomly divided into treatment group and control group. The control group was given routine glucocorticoid combined with other immunosuppressive agents. On the basis of the control group, the treatment group was supplemented with the acupoint penetration therapy instrument and the Chinese medicine patch affixed to the Shenshu acupuncture point for treatment for six months. The curative effect was compared before and after treatment and repeated renal biopsy was performed. Scion Imageβ software was used for the pathology Change Analysis. Follow-up 3 years, record the recurrence. Results The total clinical effective rate was 97.1% in the treatment group and 81.2% in the control group. The total effective rate was significantly better than that of the control group (P <0.05). Repeated renal biopsy quantitative analysis showed that: the treatment group glomerular index (GI) decreased significantly in the control group, tubulointerstitial chronic lesions index (TI) treatment group decreased, the control group unchanged. Interstitial lesions index (VI) treatment group unchanged, the control group decreased. Conclusion The traditional Chinese medicine iontophoresis has significant clinical effect on children refractory nephropathy and can significantly improve renal pathological changes. It is an effective method to treat children refractory nephropathy.