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[目的]观察紫杉醇联合顺铂(TP方案)与5-氟尿嘧啶联合顺铂(FP方案)治疗晚期食管癌的近期疗效及毒副反应。[方法]将经病理学确诊的64例晚期食管癌患者随机分为两组:试验组32例,采用TP方案化疗;对照组32例,采用FP方案化疗,每3周重复一次,连用2周期评价疗效。[结果]试验组和对照组的有效率分别为71.9%和40.6%,差异有统计学意义(P﹤0.05)。两组共同的毒性反应主要为骨髓抑制和消化道反应,TP组有肌肉关节痛。[结论]紫杉醇联合顺铂方案治疗晚期食管癌的疗效肯定,毒副反应可耐受。
[Objective] To observe the short-term efficacy and toxicity of paclitaxel plus cisplatin (TP regimen) and 5-fluorouracil combined with cisplatin (FP regimen) in the treatment of advanced esophageal cancer. [Methods] Sixty-four patients with advanced esophageal cancer confirmed by pathology were randomly divided into two groups: 32 patients in the experimental group were treated with TP chemotherapy; 32 patients in the control group were treated with FP chemotherapy and repeated every 3 weeks for 2 cycles. Evaluate the efficacy. [Results] The effective rates of the experimental group and the control group were 71.9% and 40.6% respectively, and the difference was statistically significant (P<0.05). The common toxicities in the two groups were myelosuppression and gastrointestinal reactions, and muscle and joint pain in the TP group. [Conclusion] The efficacy of paclitaxel combined with cisplatin regimen in the treatment of advanced esophageal cancer is certain, and toxic and side effects can be tolerated.