一、结核菌耐药性的概念及产生机制结核菌的耐药性系指结核菌对抗结核药物产生了一定的耐受能力而言。几乎所有的抗结核药物作用最后,由于患者机体产生耐药性而受到限制。在不同的情况下耐药性产生的快慢有很大差别,一般说来,药物浓度愈高,受到药物作用的细菌愈多则耐药性产生的愈快。但并非绝然如此,对链霉素和异烟肼的耐药性要比对胺柳酸来的快。在肺部含菌很多的病灶里比 First, the concept and mechanism of TB drug resistance TB drug resistance refers to the TB drug against tuberculosis drugs have a certain tolerance. Almost all anti-tuberculosis drug effects are ultimately limited by the patient’s resistance to the drug. In different circumstances there is a great difference in the speed of drug resistance, in general, the higher the drug concentration, the more the drug-affected bacteria, the faster the drug resistance. But not necessarily, the resistance to streptomycin and isoniazid is faster than to amine. A lot of bacteria in the lungs than in the lesions