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目的探讨Ｅ－选择素对局灶缺血性脑皮质血流的影响。方法用Ｅ－ｓｅｌｅｃｔｉｎＬｅｃｔｉｎＤｏ－ｍａｉｎ（以下Ｅ－选择素）Ｎ－末端２３－３０氨基酸残基合成的寡肽（Ｏｌｉｇｏｐｅｐｔｉｄｅ）１０ｍｇ／ｋｇ，或伪Ｅ－ｓｅｌｅｃｔｉｎ或等量生理盐水，在ＳＨＲ（自发高血压性大鼠）ＭＣＡ／ＣＣＡ（大脑中动脉／颈总动脉）闭塞２ｈ后ＣＣＡ再灌注的模型中，静脉内缓慢注入，用激光多普勒血流测定仪从ＳＨＲ缺血前１０ｍｉｎ起至ＭＣＡ／ＣＣＡ闭塞２ｈ、ＣＣＡ再灌注后３０ｍｉｎ止，在大脑皮质背侧测定脑血流的变化。结果生理盐水组、伪Ｅ－选择素和Ｅ－选择素组的局部脑血流分别是２３％、２９％和５４％，有统计学意义（Ｐ＜０．０５）。结论Ｅ－选择素能够有效地增加ＳＨＲ缺血再灌注后脑皮质的血流
Objective To investigate the effect of E-selectin on focal ischemic cerebral cortex blood flow. Methods Oligopeptide 10 mg / kg synthesized with N-terminal 23-30 amino acid residues of E-selectinLectin Do-main (hereinafter E-selectin) or pseudo-E-selectin or an equal amount of physiological saline was used in SHR Blood pressure rats) MCA / CCA (middle cerebral artery / common carotid artery) 2h after CCA reperfusion model, intravenous injection slowly, with laser Doppler flowmetry from SHR ischemia 10min to MCA / CCA occlusion 2h, CCA 30min after reperfusion, in the dorsal cerebral cortex were measured changes in cerebral blood flow. Results The regional cerebral blood flow of the normal saline group, pseudo-E-selectin and E-selectin group was 23%, 29% and 54% respectively, with statistical significance (P <0.05). Conclusion E-selectin can effectively increase the cerebral cortex blood flow after SHR ischemia-reperfusion