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硫酸乙酰肝素蛋白聚糖（HSPGs）是位于细胞表面、细胞外基质及基底膜的生物大分子物质,硫酸乙酰肝素为HSPGs带阴离子的侧链。乙酰肝素酶能特异性地水解硫酸乙酰肝素为小分子片段,从而调节细胞表面和细胞外基质与HSPGs结合的各种活性因子的生物学作用,同时还可使HSPGs上结合的负电荷减少,使基底膜上电荷屏障受损。乙酰肝素酶存在于哺乳动物的多种细胞内,尤其是免疫细胞和肿瘤细胞,故在抗肿瘤和炎症及免疫调节治疗中成为目前研究的焦点。
Heparan sulfate proteoglycans (HSPGs) are biological macromolecules located on the cell surface, extracellular matrix and basement membrane, and heparan sulfate is an anion-bearing side chain of HSPGs. Heparanase can specifically hydrolyze heparan sulfate as a small molecule fragment so as to regulate the biological effects of various active factors that bind to the surface and extracellular matrix with HSPGs, and at the same time, reduce the negative charges bound to HSPGs, Damage to the charge barrier on the basement membrane. Heparanase exists in a variety of cells in mammals, especially immune cells and tumor cells, and has become the focus of current research in anti-tumor and inflammatory and immunomodulatory therapies.