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为确定输注UVB照射白细胞是否诱导产生针对供者主要组织相容性复合(MHC)抗原的免疫耐受性,采用带有明确的MHC抗原特征的近交品系小鼠进行了研究。带有H-2k表型的CBA小鼠和带有H-2d表型的BALB/c小鼠分别用作供者和受者。体液免疫耐受性解释定义为输入未经处理供体白细胞刺激后缺乏抗体应答。研究发现输入经1200mj/cm~2UVB照射的纯化末梢血液单核白细胞不仅可以防止同种免疫作用,还可在所有受体小鼠中诱导针对供体小鼠Ⅰ类及Ⅱ类MHC抗原的体液免疫耐受性。供体血浆和血小板对此耐受性起妨碍作用。
To determine if the infusion of UVB irradiated leukocytes induced immune tolerance to donor major histocompatibility complex (MHC) antigens, inbred strain mice with defined MHC antigen characteristics were studied. CBA mice with the H-2k phenotype and BALB / c mice with the H-2d phenotype were used as donors and recipients, respectively. Humoral immune tolerance is defined as the lack of an antibody response after untreated donor leukocyte stimulation. The study found that purified peripheral blood mononuclear leukocytes irradiated at 1200 mj / cm ~ 2 UVB not only prevented alloimmunization but also induced humoral immunity to donor mouse class I and class II MHC antigens in all recipient mice Tolerance. Donor plasma and platelets interfere with this tolerance.