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目的观察聚乙二醇电解质散联合麻仁丸治疗老年功能性便秘(FC)的临床效果。方法选择60例老年FC患者随机分为试验组和对照组各30例。试验组给予聚乙二醇电解质散联合麻仁丸治疗;对照组单纯使用聚乙二醇电解质散,比较2组临床疗效用药后至首次排便时间、复发情况及用药不良反应。结果试验组治疗总有效率为96.7%高于对照组的76.7%,差异有统计学意义(P<0.05)。试验组用药后至首次排便时间为85~195(137.93±4.92)min,对照组为90~298(148.37±29.83)min,2组用药后至首次排便时间比较差异无统计学意义(P>0.05)。试验组复发率低于对照组,差异有统计学意义(P<0.05)。对照组中出现腹泻1例,后自行好转;试验组中出现腹泻1例,自行停药后好转,阵发性腹痛1例,未经处理自行好转。2组患者均未出现过敏或其他严重不良反应。结论聚乙二醇电解质散剂联合麻仁丸对老年FC的临床疗效优于其单独使用,值得临床推广。
Objective To observe the clinical effect of polyethylene glycol electrolyte powder combined with Maren pill in elderly patients with functional constipation (FC). Methods Sixty aged elderly patients with FC were randomly divided into experimental group and control group, 30 cases each. The experimental group was given polyethylene glycol electrolyte powder combined with Ma Ren Wan. The control group was treated with polyethylene glycol electrolyte alone. The clinical efficacy of the two groups was compared to the first defecation time, recurrence and adverse drug reactions. Results The total effective rate of the experimental group was 96.7% higher than that of the control group (76.7%), the difference was statistically significant (P <0.05). The first defecation time was 85 ~ 195 (137.93 ± 4.92) min in the experimental group and 90 ~ 298 (148.37 ± 29.83) min in the control group, but there was no significant difference between the two groups after first defecation (P> 0.05 ). The recurrence rate of the experimental group was lower than that of the control group, the difference was statistically significant (P <0.05). One case of diarrhea occurred in the control group, and one case of diarrhea improved in the control group. One case of diarrhea occurred in the test group, which improved after stopping drug treatment. One case developed paroxysmal abdominal pain, which improved without treatment. No allergy or other serious adverse reactions occurred in both groups. Conclusions The clinical efficacy of polyethylene glycol electrolyte powder combined with Maren pill on elderly FC is better than that of FC alone. It is worthy of clinical promotion.