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从1980～1988年,对425例原发性何杰金氏病(HD)进行了骨髓吸取活检作为常规分期的一部分,以阐明:①治疗前骨髓侵犯发病率。②从一侧髂嵴后上钻孔(trephine)活检与从两侧吸取涂片的价值。③骨髓检查对分期、治疗与结果的重要性。结果表明,425例中7例(1.7%)有骨髓侵犯,活检均为阳性,而双侧吸取仅4例显示骨髓侵犯。故单侧活检较双侧吸取阳性率高。7例骨髓侵犯中6例在骨髓检查前为Ⅳ期(Ann Arbor分期),7例均有B症状(发烧、盗汗、皮肤瘙痒及体重减轻),仅1例因骨髓检查结果使临床期别从Ⅲ_B改变为Ⅳ_B。均未因骨髓侵犯而改变治疗方案。
From 1980 to 1988, 425 patients with primary Hodgkin’s disease (HD) underwent bone marrow aspiration biopsy as part of a routine staging procedure to elucidate the incidence of bone marrow involvement before treatment. ② From the iliac crest on one side after the hole (trephine) biopsy and smear from both sides of the value. ③ bone marrow examination staging, treatment and outcome of the importance. The results showed that in 425 cases, 7 cases (1.7%) had bone marrow invasion, biopsy was positive, while bilateral suction only 4 cases showed bone marrow violations. Therefore, unilateral biopsy than bilateral suction positive rate. Six of the seven cases had bone marrow involvement before the bone marrow examination for stage IV (Ann Arbor staging), seven cases had symptoms of B (fever, night sweats, pruritus and weight loss), and only one patient had a clinical stage from the bone marrow examination Ⅲ_B changed to Ⅳ_B. Neither changed the treatment regimen due to bone marrow invasion.