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糖尿病肾病是常见的糖尿病并发症之一,其发生机制与多种因素相关。集聚蛋白是一种硫酸乙酰肝素蛋白聚糖,其羧基片段与肾脏、神经肌肉及心血管系统都有密切的联系。有研究表明集聚蛋白羧基片段在血清中的浓度与判定糖尿病肾病进展的指标有密切的联系,如肾小球滤过率、肌酐、内生肌酐清除率、尿蛋白等。本文主要阐述了集聚蛋白羧基片段与糖尿病及糖尿病肾病的关系,为糖尿病及糖尿病肾病的深入研究提供重要线索。
Diabetic nephropathy is one of the common diabetic complications, and its mechanism of occurrence is related to many factors. Aggrecan is a heparan sulfate proteoglycan whose carboxyl moiety is closely linked to the kidneys, neuromuscular and cardiovascular systems. Studies have shown that the concentration of the carboxylesterase fragment in serum is closely related to the index of judging the progress of diabetic nephropathy, such as glomerular filtration rate, creatinine, creatinine clearance, urine protein and so on. This article mainly expounds the relationship between the carboxylated fragment of agrin and diabetes mellitus and diabetic nephropathy, and provides important clues for the in-depth study of diabetes mellitus and diabetic nephropathy.