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在雄大鼠,注铜粉蓖麻油混悬液于附睾头165天后,取下丘脑、垂体、睾丸和附睾,常规固定包埋染色(包括HE、PAS和硫堇染色),光镜观察。结果表明,大部分曲细精管已受损,管腔内见大量脱落细胞,主要是精母细胞或精子细胞,偶见精原细胞、保育细胞和多核巨细胞。上述损伤细胞可见核变性或固缩成各种不规则形状。对照组无明显改变。下丘脑和垂体两组也未见明显异常。结果表明附睾头注铜抗生育作用仅限于性腺轴低水平器官。
In male rats, injection of copper powder castor oil suspension in the epididymis for 165 days, remove the thalamus, pituitary, testis and epididymis, routine fixed embedded staining (including HE, PAS and thionine staining), light microscopy. The results showed that most of the seminiferous tubules have been damaged, see a large number of exfoliated cells in the lumen, mainly spermatocytes or sperm cells, occasional spermatogonia, cells and multinucleated giant cells. The damaged cells can be seen nuclear degeneration or shrink into a variety of irregular shape. No significant change in the control group. Hypothalamus and pituitary no obvious abnormalities in both groups. The results show that epididymal injection of copper is limited to the role of gonadal axis of low-level organs.